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Differences in algorithmsused for tidal volume calculation may also resultin overestimation (SLE 5000) or underestimation(Stephanie) of the delivered volume by between 5and 20 %, and the inaccuracy of this display mayalso increase as frequency is increased (Leipalaet al

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Ofcourse, this approach presumes that the most sensitive effecthas been identified and dose–response relationshipinformation for this effect exists. Current definitions rely on a number of parameters, including clinical, microbio-logical, and histopathological features [31]

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